概述| 货号 | QC174 |
| 简介 | For use with catalog number DTM200 |
| 别名 | CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinases 2 |
全称 | Tissue Inhibitors of Metalloproteinases 2 |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 7077 (Human); 21858 (Mouse); 29543 (Rat) |
| 背景 | TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Cancer Biomarkers
- Extracellular Matrix Remodeling and Cell Migration During EMT
- ICC / IHC Images: TIMP-2
- Inflammatory Mediators
- Metalloproteases and Regulators
- MMPs, TIMPs and Related Molecules
- OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression
|
