概述| 货号 | QC152 |
| 简介 | For use with catalog numbers DRG00, SRG00, PDRG00 |
| 别名 | AGER; EC 2.7.11.22; MOK protein kinase; MOKMAPK/MAK/MRK overlapping kinase; RAGE-1; RAGE1renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; renal tumor antigen |
全称 | Receptor for Advanced Glycation End Products |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 177 (Human); 11596 (Mouse); 81722 (Rat) |
| 背景 | RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - APP Cleavage and Amyloid-beta Degradation
- Blood-brain Barrier Transporters
- Cell Structure and Signaling Molecules
- Diabetes
- Diabetic Peripheral Neuropathy
- Glucose Homeostasis
- ICC / IHC Images: RAGE
- Inflammatory Mediators
- Integrins and Associated Molecules
- Mouse Obesity Antibody Array
- Neurodegenerative Disease
- ROS and Stress Resistance
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