概述| 货号 | QC136 |
| 简介 | For use with catalog numbers DOST00, SOST00, PDOST00 |
| 别名 | BNSP; Bone sialoprotein 1; Eta-1; MGC110940; Nephropontin; OPN; osteopontin; secreted phosphoprotein 1bone sialoprotein I, early T-lymphocyteactivation 1); secreted phosphoprotein-1 (osteopontin, bone sialoprotein); Spp1; SPP-1; SPP1/CALPHA1 fusion; Urinary stone protein; uropontin |
全称 | Secreted Phosphoprotein 1 [BNSP] |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 6696 (Human); 20750 (Mouse); 25353 (Rat); 281499 (Bovine) |
| 背景 | Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad¬hesion, and migration. Its expression is upregulat¬ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 | - Adipose-derived Stem Cell Markers
- Cancer Biomarkers
- Endothelial Cell Markers and Adhesion Molecules in Angiogenesis
- Extracellular Matrix Molecules
- Gametes and Fertilization
- HIF Transcription Factors
- ICC / IHC Images: Osteopontin/OPN
- Integrins and Associated Molecules
- Osteoblast Markers
- Osteogenesis Markers
- Osteopontin and Syndecan-4 in Liver Inflammation
- Osteopontin Involvement in Cell-mediated Immunity
- Renal Markers
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