ProDots Recombinant Human IL-10 Protein (50 UG)【科瑞奥博】

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ProDots Recombinant Human IL-10 Protein (50 UG)

货号： PRD217-10 基本售价： 21643.4 元规格： 50 ug

产品信息

概述
货号	PRD217-10
简介	Supplied as ready-to-use 5 ug protein balls
别名	CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF
全称	Interleukin 10
反应种属	Human
来源	Spodoptera frugiperda,Sf 21 (baculovirus)-derived Ser19 - Asn178
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 493683 (Feline); 100135553 (Guinea Pig); 2949786 (Viral)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using MC/9‑2 mouse mast cells. Thompson-Snipes, L. et al. (1991) J. Exp. Med. 173:507. The ED₅₀ for this effect is typically 0.15-0.75 ng/mL.
溶解方法	Add ProDot directly to the medium or reconstitute at 50 μg/mL in sterile PBS.
背景	Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.
Accession #	P22301
运输条件	Blue Ice
N-terminal Sequence Analysis	Ser19
预期分子量	18.6 kDa
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献	B Cell Development and Differentiation B Cell Markers Conventional/Classical Dendritic Cells Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function gamma delta T Cells ICC / IHC Images: IL-10 IL-10 and IL-12 Influence in Dendritic Cell Maturation IL-10/Interferon Family Inflammatory Mediators Isolation, Culture, and Identification of Natural Killer Cells Lymphoma Macrophage Activation Markers Monocyte Markers Mouse Obesity Antibody Array Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells Neuroinflammation Plasmacytoid Dendritic Cells Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th1 Cells Th2 Cells Th22 Cells Th9 Cells

参考图片

1 μg/lane of ProDots^® Recombinant Human IL-10 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing major bands at 18 kDa and 16 kDa, respectively.

ProDots^® Recombinant Human IL-10 induces proliferation of a MC/9-2 mouse mast cell line. The ED₅₀ for this effect is typically 0.15-0.75 ng/mL.