ProDots Recombinant Human IL-6 Protein (250 UG)【科瑞奥博】

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ProDots Recombinant Human IL-6 Protein (250 UG)

货号： PRD206-50 基本售价： 14871.7 元规格： 250 ug

产品信息

概述
货号	PRD206-50
简介	Supplied as ready-to-use 5 ug protein balls
别名	B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta 2; IFN-beta-2; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A
全称	Interleukin 6
反应种属	Human
来源	E. coli-derived Pro29 - Met212
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using T1165.85.2.1 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED₅₀ for this effect is typically 0.2-0.8 ng/mL.
背景	IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
Accession #	Q75MH2
运输条件	Blue Ice
N-terminal Sequence Analysis	Pro29
预期分子量	20.3 kDa
SDS-PAGE	21 kDa, reducing conditions
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献	Adipocytokines Cancer Biomarkers Conventional/Classical Dendritic Cells Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function Diabetes gamma delta T Cells Glucose Homeostasis Helper T (Th) Cells HIF Transcription Factors ICC / IHC Images: IL-6 IL-6 Family Infectious Diseases Inflammatory Mediators Interactive Pathway: Adipocytokines & Insulin Signaling Interactive Pathway: Th17 Differentiation Macrophage Activation Markers Mini-review: Interleukin 6 Mouse Obesity Antibody Array Multiple Myeloma Multiple Sclerosis and Myelin Related Molecules Myeloid-derived Suppressor Cells (MDSC) Neuroinflammation Obesity Plasmacytoid Dendritic Cells Role of IL-6 in Energy Expenditure T Cell Cytokine Signaling Th17 Cells Th22 Cells Th9 Cells

参考图片

1 μg/lane of ProDots^® Recombinant Human IL-6 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at 21 and 20 kDa, respectively.

ProDots^® Recombinant Human IL-6 stimulates cell proliferation of the T1165.85.2.1 mouse plasmacytoma cell line.The ED₅₀ for this effect is typically 0.2-0.8 ng/mL.