ProDots Recombinant Human IL-2 Protein (250 UG)【科瑞奥博】

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ProDots Recombinant Human IL-2 Protein (250 UG)

货号： PRD202-50 基本售价： 12165.1 元规格： 250 ug

产品信息

概述
货号	PRD202-50
简介	Supplied as ready-to-use 5 ug protein balls
别名	aldesleukin; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF
全称	Interleukin 2
反应种属	Human
来源	E. coli-derived Ala21 - Thr153, with an N-terminal Met
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
内毒素水平	<0.01 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED₅₀ for this effect is typically 0.05-0.25 ng/mL
溶解方法	Add ProDot directly to the medium or reconstitute at 100 μg/mL in sterile 100 mM Acetic Acid.
背景	IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c). IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.
Accession #	P60568
运输条件	Blue Ice
N-terminal Sequence Analysis	Met
预期分子量	15 kDa
SDS-PAGE	13 kDa, reducing conditions
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献	BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Cancer Biomarkers Common gamma Chain Receptor Family Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Conventional/Classical Dendritic Cells Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Tfh Cell Differentiation and Function gamma delta T Cells Group 1 ILCs ICC / IHC Images: IL-2 Infectious Diseases Inflammatory Mediators Interactive Pathway: IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-2 Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells Mini-review: Cytolytic Granule-mediated Apoptosis Multiple Sclerosis and Myelin Related Molecules NCR+ILC3 Neuroinflammation Preeclampsia Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th1 Cells Th2 Cells Th9 Cells

参考图片

1 μg/lane of ProDots^® Recombinant Human IL-2 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing a single band at 13 kDa.

ProDots^® Recombinant Human IL-2 stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line. The ED₅₀ for this effect is typically 0.05-0.26 ng/mL.