ProDots Recombinant Human/Mouse/Rat Activin A Protein (50 UG)【科瑞奥博】

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ProDots Recombinant Human/Mouse/Rat Activin A Protein (50 UG)

货号： PRD338-10 基本售价： 11500.8 元规格： 50 ug

产品信息

概述
货号	PRD338-10
简介	Supplied as ready-to-use 5 ug protein balls
别名	INHBA
反应种属	Human
来源	Chinese Hamster Ovary cell line, CHO-derived Gly311-Ser426
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3624 (Human); 16323 (Mouse)
内毒素水平	<0.01 EU per 1 μg of the protein by the LAL method.
生物活性	Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. The ED₅₀ for this effect is typically 0.2-1.2 ng/mL.
溶解方法	For a stock solution, reconstitute at 100 μg/mL in 4 mM HCl, or simply roll ProDot
背景	Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).
Accession #	P08476
运输条件	Blue Ice
N-terminal Sequence Analysis	Gly311
预期分子量	13 (monomer) kDa
SDS-PAGE	14 kDa, reducing conditions, 24 kDa, non-reducing conditions
存放说明	4℃
参考文献	Activin Family Activins Airway Inflammation and Remodeling Biomarker Testing Service BMPs & Activins Influence FSH Synthesis Early Mesodermal Lineage Markers ICC / IHC Images: Activin A Macrophage Activation Markers Mini-review: Activin/Inhibin Neural Progenitor Cell Markers New Tools: for development research Red Blood Cells (RBCs) TGF-beta Superfamily

参考图片

1µg/lane of ProDots^® Recombinant Human/Mouse/Rat Activin A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing single bands at 14 kDa and 24 kDa, respectively.

ProDots^® Recombinant Human/Mouse/Rat Activin A induces hemoglobin expression in K562 chronic myelogenous leukemia cells. The ED₅₀ is typically 0.2-1.2 ng/mL.