ProDots Recombinant Human GM-CSF Protein (50 UG)【科瑞奥博】

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ProDots Recombinant Human GM-CSF Protein (50 UG)

货号： PRD215-10 基本售价： 11084.4 元规格： 50 ug

产品信息

概述
货号	PRD215-10
简介	Supplied as ready-to-use 5 ug protein balls
别名	colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; molgramostin; sargramostim
全称	Granulocyte Macrophage Growth Factor
反应种属	Human
来源	E. coli-derived Ala18 - Glu144
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is typically 6-30 pg/mL.
溶解方法	Add ProDot directly to the medium or reconstitute in the vial at 100 μg/mL in sterile PBS containing at least 0.1% human or bovineserum albumin.
背景	GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the inflammatory activation of dendritic cells, microglia, alveolar macrophages, and eosinophils. In addition, it cooperates with G-CSF in promoting tumor cell proliferation and invasion. GM-CSF signals through a receptor complex composed of GM-CSF R alpha and the Common beta Chain (beta c) with Syndecan-2 as a potential co-receptor. The beta c subunit is shared by the receptor complexes for IL-3 and IL-5.
Accession #	CAA26822
运输条件	Blue Ice
N-terminal Sequence Analysis	Ala18
预期分子量	14 kDa
SDS-PAGE	14 kDa, reducing conditions
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献	Common beta Chain Receptor Family Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Dendritic Cell Development Gametes and Fertilization gamma delta T Cells ICC / IHC Images: GM-CSF Inflammatory Mediators Isolation, Culture, and Identification of Natural Killer Cells Macrophage Activation Markers Myeloid-derived Suppressor Cells (MDSC) Natural Killer T (NKT) Cells T Cell Cytokine Signaling

参考图片

1 μg/lane of ProDots^® Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at approximately 14 kDa.

ProDots Recombinant Human GM-CSF stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED₅₀ for this effect is typically 6-30 pg/mL