ProDots Recombinant Human FGF basic (146 aa) Protein (250 UG)【科瑞奥博】

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ProDots Recombinant Human FGF basic (146 aa) Protein (250 UG)

货号： PRD233-50 基本售价： 7445.8 元规格： 250 ug

产品信息

概述
货号	PRD233-50
简介	Supplied as ready-to-use 5 ug protein balls
别名	basic fibroblast growth factor bFGF; Basic fibroblast growth factor; bFGF; FGF2; FGF-2; FGF2AS; FGFBprostatropin; fibroblast growth factor 2 (basic); GFG1; HBGF-2; HBGH-2; heparin-binding growth factor 2; NUDT6; Prostatropin
全称	Fibroblast Growth Factor basic
反应种属	Human
来源	E. coli-derived Pro143 - Ser288
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	2247 (Human); 14173 (Mouse); 281161 (Bovine); 403857 (Canine); 100033955 (Equine)
内毒素水平	<0.01 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED₅₀ for this effect is typically 0.1-0.6 ng/mL.
背景	FGF basic (FGF-2) is a growth factor that functions in angiogenesis, wound healing, tissue repair, learning and memory, and the morphogenesis of heart, bone, and brain. It is upregulated in response to inflammatory stimuli and in many tumors. FGF basic binds to FGF R1c and 2c. Its bioactivity is modulated by a number of other binding partners including heparin, Integrin alpha V beta 3, soluble FGF R1, FGF-BP, free gangliosides, Thrombospondin, Pentraxin 3/TSG-14, Fibrinogen, alpha 2-Macroglobulin, PDGF, and CXCL4/PF4. These molecules act as cellular coreceptors or adhesion partners, extracellular matrix decoys or reservoirs, and soluble scavengers or chaperones. In particular, the interaction of FGF basic with cell surface heparan sulfate proteoglycans (HSPG) is required for the binding and activation of FGF receptors.
Accession #	PO9O38
运输条件	Blue Ice
N-terminal Sequence Analysis	Ala-Pro143
预期分子量	16.5 kDa
SDS-PAGE	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献	Adult Neurogenesis Cancer Biomarkers Developmental Factors Implicated in Neurodegeneration EMT Induction FGF Family FGF Ligands Fibroblast Growth Factors and their Receptors ICC / IHC Images: FGF basic Mini-review: Fibroblast Growth Factors (FGFs) Proliferation Bioassay NR6R 3T3 Cells

参考图片

1 μg/lane of ProDots^® Recombinant Human FGF basic was resolved with SDS-PAGE under reducing (R) and non-reducing(NR) conditions and visualized with silver staining, showing a single band at 17 kDa.

ProDots^® Recombinant Human FGF basic stimulates cell proliferation of the NR6R-3T3 mouse fibroblast cell line. The ED₅₀ for this effect is 0.1-0.6 ng/mL.