ProDots Recombinant Human IL-4 Protein (5 UG)【科瑞奥博】

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ProDots Recombinant Human IL-4 Protein (5 UG)

货号： PRD204-01 基本售价： 1477.2 元规格： 5 ug

产品信息

概述
货号	PRD204-01
简介	Supplied as ready-to-use 5 ug protein balls
别名	B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra
全称	Interleukin 4
反应种属	Human
来源	E. coli-derived His25 - Ser153, with an N-terminal Met
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED₅₀ for this effect is typically 0.05-0.2 ng/mL.
溶解方法	For a stock solution, reconstitute at 100-200 μg/mL in PBS containing ≥ 0.1% human or bovine serum albumin, or simply roll ProDot
背景	IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.
Accession #	P05112
运输条件	Blue Ice
N-terminal Sequence Analysis	Met
预期分子量	15 kDa
SDS-PAGE	14kDa, reducing conditions
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
参考文献	BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Common gamma Chain Receptor Family Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Angiogenesis Cytokines and Receptors in Tfh Cell Differentiation and Function Dendritic Cell Development Eotaxin Stimulates Eosinophil Release of Preformed IL-4 gamma delta T Cells Group 2 ILCs ICC / IHC Images: IL-4 Inflammatory Mediators Interactive Pathway: IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-4 Signaling Pathways Multiple Sclerosis and Myelin Related Molecules Natural Killer T (NKT) Cells Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th2 Cells Th9 Cells

参考图片

1 μg/lane of ProDots^® Recombinant Human IL-4 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized with silver staining, showing a single band at approximately 14 kDa.

ProDots^® Recombinant Human IL-4 stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED₅₀ for this effect is typically 0.05-0.2 ng/mL.