ProDots Recombinant Human IGF-I Protein (5 UG)【科瑞奥博】

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ProDots Recombinant Human IGF-I Protein (5 UG)

货号： PRD291-01 基本售价： 664.2 元规格： 5 ug

产品信息

概述
货号	PRD291-01
简介	Supplied as ready-to-use 5 ug protein balls
别名	IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C
全称	Insulin-like Growth Factor I
反应种属	Human
来源	E. coli-derived Gly49 - Ala118
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3479 (Human); 16000 (Mouse); 24482 (Rat)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED₅₀ for this effect is typically 0.3-1.5 ng/mL.
溶解方法	Add ProDot directly to the medium or reconstitute at 200 μg/mL in sterile PBS.
背景	Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity. The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.
Accession #	P05019
运输条件	Blue Ice
N-terminal Sequence Analysis	Gly49
预期分子量	7.6 kDa
SDS-PAGE	7 kDa, reducing conditions
存放说明	4℃
纯度	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
参考文献	ALS Related Molecules Cancer Biomarkers Cytokines in Lipid/Cholesterol Metabolism Diabetes and Obesity Research gamma delta T Cells Glucose Homeostasis ICC / IHC Images: IGF-I IGF Family IGF Ligands IGF-II, Developmental Abnormalities and Genomic Imprinting Insulin-like Growth Factor (IGF) and Receptors Insulin-Like Growth Factors and Cancer Mouse Obesity Antibody Array Preeclampsia Protein/Peptide Hormones and Regulators Reproduction

参考图片

1 μg/lane of ProDots^® Recombinant Human IGF-I was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing a single band at 7 kDa.

ProDots^® Recombinant Human IGF-I stimulates proliferation in the MCF-7 human breast cancer cell line. The ED₅₀ for this effect is typically 0.3-1.5 ng/mL.