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货号： bs-18203R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-18203R
- 英文名称
- LDB2
- 中文名称
- LDB2蛋白抗体
- 别 名
- Carboxyl terminal LIM domain binding protein 1; Carboxyl terminal LIM domain protein 1; Carboxyl-terminal LIM domain-binding protein 1; CLIM 1; CLIM-1; CLIM1; LDB 1; LDB 2; LDB-2; LDB1; LDB2; LDB2_HUMAN; LIM binding domain 2; LIM domain binding 2; LIM domain binding factor 2; LIM domain binding factor CLIM 1; LIM domain binding factor CLIM1; LIM domain binding protein 2; LIM domain-binding factor CLIM1; LIM domain-binding protein 2; OTTHUMP00000158632; OTTHUMP00000217823; OTTHUMP00000217824; OTTHUMP00000217825; OTTHUMP00000217827.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Cat,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LDB2:1-100/373
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]
Function:
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.
Subcellular Location:
Nucleus.
Post-translational modifications:
Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.
Similarity:
Belongs to the LDB family.
SWISS:
O43679
Gene ID:
9079
Database links:Entrez Gene: 9079Human
Entrez Gene: 16826Mouse
Entrez Gene: 289664Rat
Omim: 603450Human
SwissProt: Q9W676Chicken
SwissProt: O43679Human
SwissProt: O55203Mouse
SwissProt: B5DF10Rat
Unigene: 714330Human
Unigene: 25785Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LDB2) Polyclonal Antibody, Unconjugated (bs-18203R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.