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货号： bs-17076R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17076R-Gold
- 英文名称
- Anti-KAT2A/GCN5/Gold
- 中文名称
- 胶体金标记的组蛋白乙酰基转移酶GCN5抗体
- 别 名
- 1110051E14Rik; AW212720; EC 2.3.1.48; GCN 5; GCN5 (general control of amino acid synthesis yeast homolog) like 2; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; Gcn5; GCN5 general control of amino acid synthesis 5 like 2; GCN5 general control of amino-acid synthesis 5-like 2 (yeast); GCN5 like 2; GCN5L2; general control of amino acid synthesis 5-like 2; General control of amino acid synthesis protein 5 like 2; General control of amino acid synthesis protein 5-like 2; General control of amino acid synthesis yeast homolog like 2; General control of amino acid synthesis, yeast, homolog-like 2; HGCN 5; HGCN5; Histone acetyltransferase GCN5; Histone acetyltransferase KAT2A; hsGCN5; K(lysine) acetyltransferase 2A; KAT2 A; KAT2A; KAT2A_HUMAN; Lysine acetyltransferase 2A; MGC102791; PCAF-b; STAF97.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 细胞生物 信号转导 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 94kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KAT2A/GCN5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]
Function:
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tats transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in all tissues tested, with most abundant expression in ovary.
Similarity:
Belongs to the GCN5 family.
Contains 1 bromo domain.
Contains 1 N-acetyltransferase domain.
Database links:Entrez Gene: 2648Human
Entrez Gene: 14534Mouse
Omim: 602301Human
SwissProt: Q92830Human
SwissProt: Q9JHD2Mouse
Unigene: 463045Human
Unigene: 218837Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.