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货号： bs-16890R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16890R-Gold
- 英文名称
- Anti-KCNIP1/Gold
- 中文名称
- 胶体金标记的A型钾离子通道调节蛋白1抗体
- 别 名
- A type potassium channel modulatory protein 1; KChIP1; KCIP1_HUMAN; Kcnip1; Kv channel interacting protein 1; MGC9; MGC95; Potassium channel interacting protein 1; VABP; Vesicle APC binding protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 细胞生物 信号转导 通道蛋白 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KCNIP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Function:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.
Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.
Database links:Entrez Gene: 30820Human
Entrez Gene: 70357Mouse
Entrez Gene: 65023Rat
Omim: 604660Human
SwissProt: Q9NZI2Human
SwissProt: Q9JJ57Mouse
SwissProt: Q8R426Rat
Unigene: 484111Human
Unigene: 252514Mouse
Unigene: 20530Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.