产品中心
当前位置：首页>产品中心Anti-SLC20A2
货号： bs-8610R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-8610R
- 英文名称
- SLC20A2
- 中文名称
- 溶质载体蛋白家族20成员2抗体
- 别 名
- Gibbon ape leukemia virus receptor 2; Gibbon leukemia virus receptor 2; GLVR 2; GLVR-2; GLVR2; hPit2; IBGC3; MLVAR; Murine leukemia virus amphotropic receptor; murine leukemia virus, amphotropic, receptor for; Phosphate transporter 2; PIT 2; PiT-2; Pit2; RAM1; S20A2_HUMAN; SLC20A2; Sodium-dependent phosphate transporter 2; Solute carrier family 20 (phosphate transporter) member 2; solute carrier family 20 (phosphate transporter), member 2; Solute carrier family 20 member 2.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 转录调节因子 细菌及病毒 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 70kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC20A2/PIT2:51-150/652 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The SLC20 family transport proteins were originally identified as retroviral receptors Glvr-1 and Ram-1, but are now designated sodium-dependent phosphate transporters 1 and 2 (PiT1 and PiT2). The PiT proteins function as sodium-phosphate cotransporters and are widely expressed, with high expression in bone, kidney and intestine. Both PiT1 and PiT2 are expressed on polarized epithelial cell membranes where they play a role in cellular phosphate homeostasis. PiT2 is a human receptor for amphotropic murine leukemia virus (A-MuLV). A-MuLV infects a variety of mammalian cell lines, including humans, making it a useful tool in gene transfer technology and as a vector for gene therapy. Retroviral vector systems are used in gene therapy that are designed to infect cells expressing PiT1 or PiT2.
Function:
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.
Subunit:
Homodimer.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Ubiquitously expressed.
DISEASE:
Defects in SLC20A2 are the cause of basal ganglia calcification, idiopathic, type 3 (IBGC3) [MIM:614540]. An autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal.
Similarity:
Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
SWISS:
Q08357
Gene ID:
6575
Database links:Entrez Gene: 6575 Human
Entrez Gene: 20516 Mouse
Entrez Gene: 29502 Rat
Omim: 158378 Human
SwissProt: Q95L97 Cat
SwissProt: Q08357 Human
SwissProt: Q80UP8 Mouse
SwissProt: Q63488 Rat
Unigene: 653173 Human
Unigene: 323901 Mouse
Unigene: 378231 Mouse
Unigene: 13642 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Positive control: mouse nephrocyte
Isotype Control Antibody: Rabbit IgG ; Secondary Antibody: Goat anti-rabbit IgG-FITC, Dilution: 1:100 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 6μg in 100 μL1X PBS containing 0.5% BSA.