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货号： bs-8361R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8361R-Gold
- 英文名称
- Anti-LRRC59/Gold
- 中文名称
- 胶体金标记的LRRC59蛋白抗体
- 别 名
- Leucine-rich repeat-containing protein 59; LRC59_HUMAN; LRRC59; PRO1855.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 细胞生物 免疫学 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRRC59
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LRRC59 (leucine rich repeat containing 59), also known as PRO1855, is a 307 amino acid protein that contains leucine-rich repeats and may play a role in protein binding events throughout the cell. The gene encoding LRRC59 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
Subunit:
Can form homodimers. Interacts with SGOL1. Interacts with FGF1.
Subcellular Location:
Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 5 LRR (leucine-rich) repeats.
Database links:
UniProtKB/Swiss-Prot: Q96AG4.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.