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货号： bs-9855R-Gold 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9855R-Gold
- 英文名称
- Anti-Sarcolipin/Gold
- 中文名称
- 胶体金标记的肌脂蛋白抗体
- 别 名
- SARCO_HUMAN; Sarcolipin; SLN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul（10nm 15nm 35nm）
- 研究领域
- 心血管 信号转导 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- IEM=1:20-200 IGS=1:20-200 GICA=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 3.7kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Sarcolipin(1-31aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]
Subunit:
Associated with calcium ATPase SERCA1.
Subcellular Location:
Sarcoplasmic reticulum membrane; Single-pass membrane protein.
Similarity:
Belongs to the sarcolipin family.
Database links:Entrez Gene: 6588 Human
Omim: 602203 Human
SwissProt: O00631 Human
Unigene: 334629 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Sarcolipin (SLN)是新近发现存在于肌浆网中的小分子膜蛋白,分子质量为3 kD,由31个氨基酸构成，与受磷蛋白(phospholamban,PLB)属于同一蛋白家族。SLN可抑制肌浆网钙泵(sarcoplasmic reticulum Ca2+ ATPase,SERCA)活性，降低其与Ca2+的亲和力，通过独立或与PLB协同作用影响SERCA活性，导致细胞内钙稳态失衡，降低心肌收缩力，从而发展为心衰。