Mouse IFN-beta Polyclonal Ab (20000 UN)
货号：
32400-1 基本售价：
4947.3 元 规格：
-
产品信息
概述| 货号 | 32400-1 |
| 别名 | Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956 |
全称 | Interferon beta | | 反应种属 | Mouse |
| 应用 | Neutralization |
| 目标/特异性 | Mouse IFN-beta
|
| 使用方法 | Neutralization: One neutralization unit is the amount of antiserum required to neutralize one unit of mouse interferon beta (Mu-IFN-beta ) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) J. Virol. 37, 755-758] using L929 cells and EMCV as the challenge virus. In this antiviral assay for interferon, about 2.5 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined by use of a laboratory standard calibrated with respect to the international reference standard for Mu-IFN-beta provided by the National Institutes of Health [Gb02-902-511]. This material is prepared specifically for effective neutralization of Mu-IFN-beta.
|
| 来源 | Polyclonal Rabbit Serum |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3456 (Human); 15977 (Mouse); 24481 (Rat) |
| 应用文献 |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
Immunol. Cell Biol., 2011;89(0):706-15.
Species: Mouse
Sample Type: Serum
Application: ELISA Development
A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression.
Authors: Joshi VD, Kalvakolanu DV, Chen W, Zhang L, Kang TJ, Thomas KE, Vogel SN, Cross AS
J. Interferon Cytokine Res., 2006;26(10):739-47.
Species: Mouse
Sample Type: Serum
Application: ELISA Development |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant mouse IFN-beta |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 背景 | Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS. |
| 运输条件 | Dry Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Conventional/Classical Dendritic Cells
- Cytokines and Receptors in Angiogenesis
- IL-10/Interferon Family
- Infectious Diseases
- Plasmacytoid Dendritic Cells
- Th9 Cells
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