Phospho-p73 (Tyr99) Antibody
货号：
4665S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4665S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The p53 family member, p73, exists in multiple isoforms/splice variants and can induce apoptosis and cell cycle arrest in response to DNA damage via its activity as a transcription regulator (1-3). Upon DNA damage, p73 is phosphorylated at Tyr99 by c-Abl, causing translocation to the nuclear matrix (4). DNA damage-induced acetylation of p73 at Lys321 by the acetyltransferase p300 has also been reported to enhance transcription of genes including that of p53AIP1 (5). Another report, however, indicates that p300 does not acetylate full length p73 in vivo (6).p53家族成员，p73，以多种亚型/剪接变异体存在，它可以通过转录调节器的活性诱导细胞凋亡和细胞周期阻滞以应答DNA损伤（1-3）。 DNA损伤后，p73的Tyr99被c-Abl磷酸化，引起核基质迁移（4）。 DNA损伤诱导p73的Lys321乙酰化，该过程由乙酰转移酶p300介导，已报道它以增强包括P53AIP1（5）在内的基因转录。然而，另一份报告表明，p300不能在体乙酰化全长p73（6）。 |
| 存放说明 | -20C |
| 计算分子量 | 80 |
参考图片Western blot analysis of extracts from HT-1376 cells, untreated or pervanadate-treated ( 1 mM, 20 minutes), using Phospho-p73 (Tyr99) Antibody. |
