Phospho-p40phox (Thr154) Antibody
货号：
4311S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4311S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-p40phox (Thr154) Antibody detects endogenous levels of p40phox only when phosphorylated at threonine 154. This antibody does not cross-react with other phosphorylated phox subunits. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The phagocytic NADPH oxidase is a multiprotein enzyme that catalyzes the reduction of oxygen to superoxide in response to invasion of pathogens into the body. The NADPH oxidase consists of 6 subunits, the membrane-bound p91phox and p22phox heterodimer (also known as cytochrome b558), the cytoplasmic complex of p40phox, p47phox and p67phox, and the small GTPase Rac2. Activation of NADPH oxidase is initiated by phosphorylation of the cytosolic complex, which induces comformational changes of the complex and ultimately leads to the translocation of the cytoplasmic complex to the membrane to form an active enzyme with cytochrome b558 (1). Thr154 and Ser315 of p40 phox have been identified as PKC phosphorylation sites modified during activation of the phagocyte NADPH oxidase (2). |
| 存放说明 | -20C |
| 计算分子量 | 40 |
参考图片Western blot analysis of extracts from THP1 cells, untreated or PMA-treated, and guinea pig neutrophils, untreated or fMLP-treated, using Phospho-p40phox (Thr154) Antibody.Western免疫印迹。用Phospho-p40phox (Thr154) Antibody研究未经处理的和经PMA处理的THP1细胞的细胞提取液和未经处理和经fMLP处理的豚鼠噬中性粒细胞的细胞提取液。 |
