Phospho-Numb (Ser276) Antibody
货号：
4140S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4140S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Numb (Ser276) Antibody detects endogenous levels of Numb protein only when phosphorylated on Ser276. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Numb contains an amino-terminal phosphotyrosine-binding (PTB) domain and carboxy-terminal endocytic binding motifs for α-adaptin and EH (Eps15 homology) domain-containing proteins, indicating a role in endocytosis (1,2). There are four mammalian Numb splicing isoforms that are differentially expressed and may have distinct functions (3-5). Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch (6). The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates (7,8). The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling (9). |
| 存放说明 | -20C |
| 计算分子量 | 72, 74 |
参考图片Western blot analysis of extracts from Ramos and HeLa cells, untreated or treated with TPA (Phorbol-12-Myristate-13-Acetate, 200 nM for 30 min) or λ-phosphatase, using Phospho-Numb (Ser276) Antibody (upper) or Numb (C29G11) Rabbit mAb #2756 (lower).对经过TPA(Phorbol-12-Myristate-13-Acetate, 200 nM 30分钟)或λ-磷酸酶，处理或未处理的Ramos 和HeLa细胞提取物进行western blot分析，使用Phospho-Numb (Ser276) 抗体(上) or Numb (C29G11) Rabbit mAb #2756 (下). |
