Phospho-NuMA (Ser395) Antibody
货号：
3429S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3429S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | The nuclear mitotic apparatus protein (NuMA) is a coiled coil protein involved in the formation and maintenance of the mitotic spindle. NuMA plays a role in chromatin organization during interphase, which influences mammary epithelial differentiation (1,2). During apoptosis, carboxy-terminal cleavage of NuMA may amplify signaling in the cell death pathway (2). NuMA is phosphorylated at numerous sites, with phosphorylation at Ser395 occurring in an ATM/ATR-dependent manner in response to DNA damage (3,4).核有丝分裂器蛋白(NuMA)是一种参与有丝分裂纺锤体形成和维持的卷曲蛋白。NuMA在分裂间期的染色质组织过程起其重要作用，从而影响乳腺细胞分化(1,2)。凋亡过程中，NuMA的羧基末端清除可以放大细胞死亡信号通路。NuMA含有多个磷酸化位点，ATM/ATR依赖方式发生的丝氨酸395位磷酸化能够响应DNA损伤(3,4)。 |
| 存放说明 | -20C |
| 计算分子量 | 238 |
参考图片Western blot analysis of extracts from M059K cells, untreated or UV-treated, using Phospho-NuMA (Ser395) Antibody.western blot检测未处理和紫外处理的M059K细胞提取物，使用的抗体为Phospho-NuMA (Ser395) Antibody。 |
