Non-phospho (Active) β-Catenin (Ser33/37/Thr41) Antibody
货号:
4270S 基本售价:
3980.0 元 规格:
-
产品信息
概述货号 | 4270S |
反应种属 | Human/Mouse/Rat/Monkey |
来源宿主 | Rabbit |
应用 | W |
目标/特异性 | Non-phospho-β-catenin (Ser33/37/Thr41) Antibody detects endogenous levels of β-catenin when residues Ser33, Ser37 and Thr41 are not phosphorylated. |
使用方法 | WB(1:1000) |
性能供应商 | CST |
背景 | β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). |
存放说明 | -20C |
计算分子量 | 92 |