| 货号 | 9312S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Tyk2 Antibody detects endogenous levels of total Tyk2. No cross-reactivity was detected with other family members at physiological conditions. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Tyk2, a member of the Jak family of protein tyrosine kinases, associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and interferon-alpha and beta (1-3). Following ligand binding, Tyk2 is activated by phosphorylation on Tyr1054 and/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-beta signaling cascade (5). |
| 存放说明 | -20C |
| 计算分子量 | 134 |
| 参考文献 | 1 . Velazquez, L. et al. (1995) J. Biol. Chem. 270, 3327-34. 2 . Stahl, N. et al. (1994) Science 263, 92-5. 3 . Leonard, W.J. and OShea, J.J. (1998) Annu Rev Immunol 16, 293-322. 4 . Gauzzi, M.C. et al. (1996) J Biol Chem 271, 20494-500. 5 . Rani, M.R. et al. (1999) J. Biol. Chem. 274, 32507-11. |
Western blot analysis of extracts from Raji and Jurkat cells, using Tyk2 Antibody.Western免疫印迹。用Tyk2 抗体研究Raji 和 Jurkat 细胞的细胞抽提液。 |
