| 货号 | 4403S |
| 反应种属 | Human/Mouse/Rat/Bovine |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | TWEAK Receptor/Fn14 Antibody detects endogenous levels of total TWEAK Receptor/Fn14 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The receptor for TWEAK, fibroblast growth factor-inducible 14 (Fn14), is a member of the TNF superfamily of receptors thought to be involved in cell growth, adhesion and migration (1). Its expression is regulated by a number of different growth factors (1,2). Elevated expression is also seen in some cancers including hepatocellular carcinomas (3), glioblastomas (4), and pancreatic cancer (5). The receptor contains a binding site for members of the TNFR-associated factor (TRAF) family that promotes the activation of NF-κB (1,6). Recent studies have suggeted some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity and cancer treatment (7-9). |
| 存放说明 | -20C |
| 计算分子量 | 14-17 |
| 参考文献 | 1 . Wiley, S.R. et al. (2001) Immunity 15, 837-46. 2 . Nakayama, M. et al. (2003) J. Immunol. 170, 341-8. 3 . Feng, S.L. et al. (2000) Am. J. Pathol. 156, 1253-61. 4 . Tran, N.L. et al. (2003) Am. J. Pathol. 162, 1313-21. 5 . Han, H. et al. (2002) Cancer Res. 62, 2890-6. 6 . Brown, S.A. et al. (2003) Biochem J. 371, 395-403. 7 . Desplat-Jégo, S. et al. (2005) Clin Immunol 117, 15-23. 8 . Mueller, A.M. et al. (2005) J Neuroimmunol 159, 55-65. 9 . Winkles, J.A. et al. (2006) Cancer Lett 235, 11-7. |
Western blot analysis of extracts from HT-1080, PC3 and HT29 cell lines, using TWEAK Receptor/Fn14 Antibody.Western免疫印迹。用TWEAK Receptor/Fn14 Antibody研究HT-1080, PC3 和 HT29 细胞系的细胞提取液。 |
