TWEAK Antibody【科瑞奥博】

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TWEAK Antibody

货号： 4437S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	4437S
反应种属	Human
来源宿主	Rabbit
应用	W
目标/特异性	TWEAK Antibody detects recombinant and transfected levels of TWEAK protein.
使用方法	WB(1:1000)

性能
供应商	CST
灵敏度	Recombinant
背景	TWEAK (TNFSF12/Apo-3L) is a member of the TNF superfamily of cytokines that are typically involved in immune regulation, inflammation, and apoptosis (1,2). TWEAK mRNA is expressed in a variety of tissues and cell lines, with higher levels observed in the heart, brain, skeletal muscle and within the immune system (1). Like other family members TWEAK is a type II transmembrane protein that can also be proteolytically processed to form a soluble cytokine. Soluble TWEAK is a weak inducer of apoptosis in some cell lines (1). The receptor for TWEAK, known as TWEAKR or fibroblast growth factor inducible 14 (Fn14), is a relatively small member of the TNF receptor family (3). TWEAK signaling has been associated with apoptosis, proliferation, migration, angiogenesis, and inflammation (4). Recent studies have suggested some therapeutic potential of TWEAK and its receptor signaling in regards to autoimmunity, cancer, and vascular injury (5-8).
存放说明	-20C
计算分子量	30
参考文献	1 . Chicheportiche, Y. et al. (1997) J Biol Chem 272, 32401-10. 2 . Marsters, S.A. et al. (1998) Curr Biol 8, 525-8. 3 . Wiley, S.R. et al. (2001) Immunity 15, 837-46. 4 . Wiley, S.R. and Winkles, J.A. (2003) Cytokine Growth Factor Rev 14, 241-9. 5 . Desplat-Jégo, S. et al. (2005) Clin Immunol 117, 15-23. 6 . Mueller, A.M. et al. (2005) J Neuroimmunol 159, 55-65. 7 . Winkles, J.A. et al. (2006) Cancer Lett 235, 11-7. 8 . Ortiz, A. et al. (2009) Cytokine Growth Factor Rev 20, 251-8.

参考图片

Western blot analysis of recombinant protein containing the extracellular domain of human TWEAK, using TWEAK Antibody.Western免疫印迹。用 TWEAK Antibody研究融合了胞外区域的人源 TWEAK蛋白。

Western blot analysis of extracts from 293 cells, mock transfected (-) or transfected with a construct overerexpressing human TWEAK (+), using TWEAK Antibody.Western免疫印迹。用TWEAK Antibody研究对照转染 (-) 和经转染了过表达人源TWEAK (+)的293 细胞系的细胞提取液。