| 货号 | 46702S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | WB, IP |
| 目标/特异性 | TWIST1 Antibody detects endogenous levels of total TWIST1 protein. |
| 使用方法 | W IP |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | TWIST1 is a basic helix-loop-helix (b-HLH) transcription factor that functions as a master regulator of embryonic morphogenesis and plays essential roles in mesenchymal differentiation and osteogenic determination (1-3). Mutations affecting the b-HLH domain of the TWIST1 gene have been associated with Saethre-Chotzen syndrome, an autosomal dominant craniosynostosis disorder causing craniofacial and limb abnormalities (4,5). TWIST1 is upregulated in various human tumors and may play a role in EMT (epithelial-mesenchymal transition) and metastasis (6,7). Upregulation of TWIST1 may contribute to resistance to Taxol and microtubule regulating drugs in tumors (8). |
| 存放说明 | -20C |
| 计算分子量 | 26 |
| 参考文献 | 1 . Thisse, B. et al. (1987) Nucleic Acids Res. 15, 3439-3453. 2 . Lee, M.S. et al. (1999) J. Cell Biochem. 75, 566-577. 3 . Chen, Z.F. and Behringer, R.R. (1995) Genes Dev. 9, 686-699. 4 . Howard, T.D. et al. (1997) Nat. Genet. 15, 36-41. 5 . Connerney, J. et al. (2006) Dev. Dyn. 235, 1345-1357. 6 . Watanabe, O. et al. (2004) Anticancer Res. 24, 3851-3856. 7 . Yang, J. et al. (2004) Cell 117, 927-939. 8 . Wang, X. et al. (2004) Oncogene 23, 474-482. |
Western blot analysis of extract from SH-SY5Y cells using TWIST1 Antibody. |
