| 货号 | 2937S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | TP/ECGF1 Antibody detects endogenous levels of human TP/ECGF1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate (1). This intracellular enzyme is capable of both promoting angiogenesis and inhibiting apoptosis. Thymidine phosphorylase catalytic activity is required for its angiogenic function (2,3). Increased expression of TP/PD-ECGF is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis (4,5). Alternatively, TP can activate fluorouracil derivative (DFUR) prodrugs and increase the antitumor activity of the related treatment (1,5). The use of thymidine phosphorylase as a cancer therapeutic target has been studied extensively, with emphasis on either inhibiting TP enzymatic activity or increasing enzyme induction with concomitant DFUR treatment (1,5). |
| 存放说明 | -20C |
| 计算分子量 | 50, 60 |
| 参考文献 | 1 . Rooseboom, M. et al. (2004) Pharmacol Rev 56, 53-102. 2 . Moghaddam, A. and Bicknell, R. (1992) Biochemistry 31, 12141-6. 3 . Furukawa, T. et al. (1992) Nature 356, 668. 4 . Toi, M. et al. (2005) Lancet Oncol 6, 158-66. 5 . Liekens, S. et al. (2007) Biochem Pharmacol 74, 1555-67. |
Western blot analysis of extracts from human THP-1 cells, untreated or LPS-treated overnight, using TP/ECGF1 Antibody. Western blot 检测人THP-1细胞提取物，未处理 (-)或 LPS过夜处理，使用抗体为TP/ECGF1 Antibody。 | |
Western blot analysis of extracts from COS cells transfected with human ECGF1 using TP/ECGF1 Antibody. Western blot 检测COS 细胞提取物，人ECGF1转染，使用抗体为TP/ECGF1 Antibody。 |
