Toll-like Receptor 2 Antibody【科瑞奥博】

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Toll-like Receptor 2 Antibody

货号： 2229S 基本售价： 3360.0 元规格： -

产品信息

概述
货号	2229S
反应种属	Human/Monkey
来源宿主	Rabbit
应用	W
目标/特异性	Toll-like Receptor 2 Antibody detects endogenous levels of total TLR2 protein. Cross reactivity was not detected with other family members at physiological conditions.
使用方法	WB(1:1000)

性能
供应商	CST
灵敏度	Endogenous
背景	Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasm.
存放说明	-20C
计算分子量	90-105
参考文献	1 . Akira, S. (2003) J Biol Chem 278, 38105-8. 2 . Beutler, B. (2004) Nature 430, 257-63. 3 . Dunne, A. and ONeill, L.A. (2003) Sci STKE 2003, re3. 4 . Medzhitov, R. et al. (1997) Nature 388, 394-7. 5 . Schwandner, R. et al. (1999) J Biol Chem 274, 17406-9. 6 . Takeuchi, O. et al. (1999) Immunity 11, 443-51. 7 . Alexopoulou, L. et al. (2001) Nature 413, 732-8. 8 . Zhang, F.X. et al. (1999) J Biol Chem 274, 7611-4. 9 . Horng, T. et al. (2001) Nat Immunol 2, 835-41. 10 . Oshiumi, H. et al. (2003) Nat Immunol 4, 161-7. 11 . Muzio, M. et al. (1997) Science 278, 1612-5. 12 . Wesche, H. et al. (1997) Immunity 7, 837-47. 13 . Suzuki, N. et al. (2002) Nature 416, 750-6. 14 . Irie, T. et al. (2000) FEBS Lett 467, 160-4.

参考图片

Western blot analysis of extracts from THP-1 cell lines, stimulated with 200 µM TPA overnight, using Toll-like Receptor 2 Antibody.Western免疫印迹。用Toll-like Receptor 2 Antibody研究经200 µM TPA处理过夜的THP-1细胞系的细胞提取液。