| 货号 | 2298S |
| 反应种属 | Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Thioredoxin 1 Antibody (Mouse/Rat Preferred) detects endogenous levels of total mouse and rat thioredoxin 1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond which is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (Trx1) and mitochondrial thioredoxin 2 (Trx2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, as it acts as a negative regulator of the proapoptotic kinase ASK1 (3) Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 12 |
| 参考文献 | 1 . Watson, W.H. et al. (2004) Toxicol Sci 78, 3-14. 2 . Burke-Gaffney, A. et al. (2005) Trends Pharmacol Sci 26, 398-404. 3 . Saitoh, M. et al. (1998) EMBO J 17, 2596-606. 4 . Callister, M.E. et al. (2007) Intensive Care Med 33, 364-7. 5 . Callister, M.E. et al. (2006) Thorax 61, 521-7. |
Western blot analysis of extracts from various cell lines, using Thioredoxin 1 Antibody (Mouse/Rat Preferred). 对多个细胞系使用Thioredoxin 1 Antibody（小鼠/大鼠首选）进行Western blot分析。 |
