| 货号 | 12305S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Thap11/Ronin Antibody recognizes endogenous levels of total Thap11/Ronin protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Thanatos-associated protein (Thap) proteins are a family of cellular factors that are characterized by an evolutionarily conserved protein motif similar to the DNA-binding domain of Drosophila P element transposase (1). There are 12 known human Thap proteins that all act as site-specific DNA-binding factors involved in transcriptional regulation, cell proliferation, chromatin modification, and apoptosis (2-4). Human Thap11 has been shown to suppress cell growth through transcriptional suppression of c-Myc (5). The mouse homolog of Thap11, Ronin, has been identified as an essential factor underlying embryogenesis in mouse embryonic stem cells (6). |
| 存放说明 | -20C |
| 计算分子量 | 49 |
| 参考文献 | 1 . Roussigne, M. et al. (2003) Trends Biochem Sci 28, 66-9. 2 . Cayrol, C. et al. (2007) Blood 109, 584-94. 3 . Macfarlan, T. et al. (2005) J Biol Chem 280, 7346-58. 4 . Roussigne, M. et al. (2003) Oncogene 22, 2432-42. 5 . Zhu, C.Y. et al. (2009) Cell Death Differ 16, 395-405. 6 . Volchegorskiĭ, I.A. et al. Vopr Med Khim 37, 86-9. |
Western blot analysis of extracts from various cell lines using Thap11/Ronin Antibody. 使用Thap11/Ronin抗体对多种细胞提取物进行western blot分析。 |
