| 货号 | 4916S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | STIM1 Antibody detects endogenous levels of total STIM1 protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Ca2+ is a key second messenger in many intracellular signaling pathways. Ca2+ signals control many cellular functions ranging from short-term responses such as contraction and secretion to longer-term regulation of cell growth and proliferation (1,2). Stromal interaction molecules (STIMs) function as Ca2+ sensors that detect changes in Ca2+ content in intracellular Ca2+ stores (3). STIM1 is conserved, ubiquitously expressed, and functions as an endoplasmic reticulum (ER) Ca2+ sensor that migrates from the ER Ca2+ store to the plasma membrane where it activates calcium-release-activated calcium (CRAC) channels when the ER Ca2+ store is low (4). STIM1 is a potential tumor suppressor; defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors (5). STIM1 can either homodimerize or form heterodimers with STIM2. STIM2 possesses a high sequence identity to STIM1 and can function as an inhibitor of STIM1-mediated plasma membrane store-operated Ca2+ entry (6). However, further investigation is required to elucidate the true physiological function of STIM2. |
| 存放说明 | -20C |
| 计算分子量 | 85 |
| 参考文献 | 1 . Berridge, M.J. et al. (2000) Nat Rev Mol Cell Biol 1, 11-21. 2 . Berridge, M.J. et al. (2003) Nat Rev Mol Cell Biol 4, 517-29. 3 . Zheng, L. et al. (2008) Biochem Biophys Res Commun 369, 240-6. 4 . Zhang, S.L. et al. (2005) Nature 437, 902-5. 5 . Manji, S.S. et al. (2000) Biochim Biophys Acta 1481, 147-55. 6 . Soboloff, J. et al. (2006) Curr Biol 16, 1465-70. |
Western blot analysis of extracts from NIH/3T3, PC12 and COS cells using STIM1 Antibody. 对NIH/3T3, PC12和COS细胞裂解液使用STIM1抗体进行Western blot分析。 |
