| 货号 | 9362S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Stat6 Antibody detects endogenous levels of total Stat6 protein. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Upon activation by Janus kinases, Stat6 translocates to the nucleus where it regulates cytokine-induced gene expression. Stat6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13 (1-4). In addition, Stat6 is activated by IFN-α in B cell lines, where it forms transcriptionally active complexes with Stat2 and p48 (5,6). Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling (7). |
| 存放说明 | -20C |
| 计算分子量 | 110 |
| 参考文献 | 1 . Nelms, K. et al. (1999) Ann. Rev. Immunol. 17, 701-738. 2 . Malabarba, M.G. et al. (1996) Biochem. J. 319, 865-872. 3 . Hou, J. et al. (1994) Science 265, 1701-1706. 4 . Quelle, F.W. et al. (1995) Mol. Cell. Biol. 15, 3336-3343. 5 . Takeda, K. et al. (1996) Nature 380, 627-630. 6 . Gupta, S. et al. (1999) J. Immunol. 163, 3834-3841. 7 . Woetmann, A. et al. (2003) J. Biol. Chem. 278, 2787-2791. |
Western blot analysis of extracts from various cell lines, using Stat6 Antibody.Western免疫印迹。用Stat6 Antibody研究不同细胞系的细胞提取液。 |
