| 货号 | 3388S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | RRM1 Antibody detects endogenous levels of total RRM1 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle but downregulated in quiescent cells (1). RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated to resistance to chemotherapy in non-small-cell lung cancer (2-4).核糖核酸还原酶能够催化三磷酸核苷酸(dNTPs)合成的限速步骤。调节性亚基M1 (RRM1)存在于整个细胞分化周期但是在静止期细胞表达下调(1)。RRM1参与致癌作用和肿瘤进程，其表达和非小细胞肺癌化疗治疗抵抗相关联(2-4)。 |
| 存放说明 | -20C |
| 计算分子量 | 90 |
| 参考文献 | 1 . Mann, G.J. et al. (1988) Cancer Res 48, 5151-6. 2 . Zheng, Z. et al. (2007) N Engl J Med 356, 800-8. 3 . Ceppi, P. et al. (2006) Ann Oncol 17, 1818-25. 4 . Bepler, G. et al. (2006) J Clin Oncol 24, 4731-7. |
Western blot analysis of extracts from various cell types using RRM1 Antibody.Western blot方法检测各种类型的细胞提取物，使用的抗体为 RRM1 Antibody。 |
