| 货号 | 4102S |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ROR1 Antibody detects transfected levels of ROR1 proteins. It does not cross-react with ROR2. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Transfected Only |
| 背景 | ROR1 and ROR2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. They are characterized by the presence of extracellular frizzled-like cysteine-rich domains and membrane-proximal kringle domains, both of which are assumed to mediate protein-protein interactions (1-3). The ROR family RTKs are evolutionarily conserved among Caenorhabditis elegans, Drosophila, mice, and humans (1,4). Although the functions of ROR kinases are unknown, similarities between ROR and MuSK and Trk kinases have led to speculation that ROR kinases regulate synaptic development. CAM-1, a C. elegans ortholog of the ROR family RTKs, plays several important roles in regulating cellular migration, polarity of asymmetric cell divisions, and axonal outgrowth of neurons during nematode development (4). mROR1 and mROR2 may play differential roles during the development of the nervous system (5). |
| 存放说明 | -20C |
| 计算分子量 | 135 |
| 参考文献 | 1 . Al-Shawi, R. et al. (2001) Dev Genes Evol 211, 161-71. 2 . Nomi, M. et al. (2001) Mol Cell Biol 21, 8329-35. 3 . Roszmusz, E. et al. (2001) J Biol Chem 276, 18485-90. 4 . Forrester, W.C. et al. (1999) Nature 400, 881-5. 5 . Oishi, I. et al. (1999) Genes Cells 4, 41-56. |
Western blot analysis of extracts from HEK293 cells, untransfected or transfected with HA-tagged mROR1, using ROR1 Antibody (upper) or HA-tag Antibody #2362 (lower).用ROR1 Antibody (上)或HA-tag Antibody #2362 (下)对未转染或转染了HA-tagged mROR1的HEK293 细胞的提取物进行免疫印迹检测。 |
