| 货号 | 5311S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PTP1B Antibody detects endogenous levels of total PTP1B protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Protein-tyrosine phosphatase 1B (PTP1B) is the original member of the protein tyrosine phosphatase (PTP) family of proteins (1). PTP1B is highly expressed in insulin-responsive tissues and negatively regulates insulin, as well as integrin, through dephosphorylation of phosphotyrosine residues (2-4). PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes (5). |
| 存放说明 | -20C |
| 计算分子量 | 50 |
| 参考文献 | 1 . Liang, F. et al. (2005) J Biol Chem 280, 24857-63. 2 . Kenner, K.A. et al. (1996) J Biol Chem 271, 19810-6. 3 . Klaman, L.D. et al. (2000) Mol Cell Biol 20, 5479-89. 4 . Liu, F. et al. (1998) Curr Biol 8, 173-6. 5 . Elchebly, M. et al. (1999) Science 283, 1544-8. |
Western blot analysis of extracts from various cell lines using PTP1B Antibody. Wetern blot检测多种细胞系提取物，所用抗体为PTP1B Antibody。 |
