| 货号 | 12985S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | PSMD10/Gankyrin Antibody recognizes endogenous levels of total PSMD10/Gankyrin protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | PSMD10/Gankyrin is an ankyrin-repeat chaperone protein that is involved in the assembly of the 19S regulatory particle of the proteasome (1). Reasearch studies have demonstrated that PSMD10 is oncogenic and is overexpressed in hepatocullar carcinomas (2). Investigators believe the oncogenicity of PSMD10 may be linked to its ability to bind and regulate the stability and activity of pRB, CDK4, MDM2, and RelA (2-5). |
| 存放说明 | -20C |
| 计算分子量 | 25 |
| 参考文献 | 1 . Xie, Y. (2010) J Mol Cell Biol 2, 308-17. 2 . Higashitsuji, H. et al. (2000) Nat Med 6, 96-9. 3 . Dawson, S. et al. (2002) J Biol Chem 277, 10893-902. 4 . Higashitsuji, H. et al. (2005) Cancer Cell 8, 75-87. 5 . Higashitsuji, H. et al. (2007) Biochem Biophys Res Commun 363, 879-84. |
Western blot analysis of extracts from various cell lines using PSMD10/Gankyrin Antibody.Western blot检测多种细胞提取物，使用的抗体是PSMD10/Gankyrin Antibody。 | |
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human PSMD10 (hPSMD10-Myc/DDK; +), using PSMD10/Gankyrin Antibody.Western blot分析293T细胞提取物，对照未转染（-）或转染了Myc/DDK标签的全长人源的PSMD10 (hPSMD10-Myc/DDK; +)，使用的抗体是PSMD10/Gankyrin Antibody。 |
