| 货号 | 3622S |
| 反应种属 | Human/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Presenilin 1 Antibody detects endogenous levels of the carboxy-terminal fragment of presenilin 1 (~22 kDa). The antibody detects the full length protein (55k Da) to a lesser extent. |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Presenilin 1 and presenilin 2 are transmembrane proteins belonging to the presenilin family. Mutation of presenilin genes has been linked to early onset of Alzheimer disease, probably due to presenilins associated γ-secretase activity for amyloid-β protein processing (1,2). Endogenous presenilin mainly exists in a heterodimeric complex formed from the endoproteolytically processed amino-terminal (34 kDa) and carboxy-terminal (~20, 22, 23 kDa) fragments (CTF) (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 22 (C-terminal fragment). 55 (full-length). |
| 参考文献 | 1 . Haass, C. and De Strooper, B. (1999) Science 286, 916-9. 2 . Kimberly, W.T. et al. (2000) J. Biol. Chem. 275, 3173-3178. 3 . Kim, T.W. et al. (1997) J. Biol. Chem. 272, 11006-11010. |
Western blot analysis of extracts from HeLa, SK-N-MC and COS cells, using Presenilin 1 Antibody. Western blot分析HeLa、SK-N-MC和COS细胞提取物，使用的抗体是Presenilin 1 Antibody 兔多抗。 |
