MyD88 Antibody
货号：
3699S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 3699S |
| 反应种属 | Human/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | MyD88 Antibody detects endogenous levels of total MyD88 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-3). TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IκB that normally maintains NF-κB inactivity by sequestering it in the cytoplasm. |
| 存放说明 | -20C |
| 计算分子量 | 33 |
参考图片Western blot analysis of extracts from HeLa cells, either mock transfected or transfected with MyD88, using MyD88 Antibody.Western免疫印迹。用MyD88 Antibody研究未转染和转染了MyD88的HeLa细胞的细胞提取液。 |
Western blot analysis of extracts from Jurkat, K562 and Raji cells, using MyD88 Antibody. |
