MTMR3 Antibody
货号：
12443S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 12443S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | MTMR3 Antibody recognizes endogenous levels of total MTMR3 protein. This antibody also cross-reacts with a protein of unknown origin at 48 kDa. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Myotubularin-related proteins are a family of phosphatases with emerging roles in cellular signaling and membrane trafficking (1,2). MTMR3 (Myotubularin-related protein 3), also known as FYVE-DSP1, contains an amino terminal pleckstrin homology (PH) domain and a carboxyl terminal FYVE domain. MTMR3 was first reported as a dual-specific phosphatase, having phosphatase activity toward phosphorylated serine, threonine, and tyrosine residues (3). Subsequent research studies reported that MTMR3 has phosphatase activity toward phosphoinositides, including phosphatadylinositol-3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (4). Accumulation of PI3P by the class III phosphoinositide 3-kinase Vps34 is a key element in autophagosome formation (5). Inhibition of PI3P by MTMR3 can play an important role in suppressing autophagsome formation (6). |
| 存放说明 | -20C |
| 计算分子量 | 130-150 |
参考图片Western blot analysis of extracts from various cell lines using MTMR3 Antibody. Western blot 分析不同细胞系的提取物，使用的抗体是MTMR3 Antibody。 |
