| 货号 | 4783S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | hnRNP LL Antibody detects endogenous levels of total hnRNP LL protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Heterogeneous nuclear ribonucleoprotein L-like (hnRNP LL) is a nuclear RNA-binding protein that shares 69% amino acid homology with hnRNP L, a component of hnRNP complex that regulates mRNA formation, packaging, and processing (1). hnRNP LL is induced in activated T cells and functions as a critical regulator of alternative splicing of CD45, a tyrosine phosphatase crucial for T cell development and activation (2). hnRNP LL also regulates the splicing of CD44 and Stat5a (2). The four isoforms of hnRNP LL are generated by alternative splicing and are widely expressed in human tissues (3).Heterogeneous nuclear ribonucleoprotein L-like (hnRNP LL)是一个细胞核RNA结合蛋白，它与hnRNP L蛋白共有69% 氨基酸同源序列，hnRNP L是hnRNP复合物的组分，能够调控mRNA生成，包装以及加工(1)。 hnRNP LL蛋白在活化的T细胞中被诱导，并且可作为对T细胞发育和激活至关重要的酪氨酸磷酸酶CD45选择性剪接的关键调控因子(2)。hnRNP LL 还能够调控CD44 和Stat5a的选择性剪接(2)。hnRNP LL有四个异构体，都是通过选择性剪接产生的，并且在人类组织中广泛表达(3)。 |
| 存放说明 | -20C |
| 计算分子量 | 61 |
Western blot analysis of extracts from Hep G2 and HeLa cells using hnRNP LL Antibody. 使用hnRNP LL Antibody，免疫印迹（Western blot）分析Hep G2和HeLa细胞系裂解物。 |
