| 货号 | 4699S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | hnRNP K (A222) Antibody detects endogenous levels of total hnRNP K protein. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) belongs to a family of RNA binding multiprotein complexes (hnRNP proteins) that facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm (1-3). hnRNP K contains three unique structural motifs termed KH domains that bind poly(C) DNA and RNA sequences (4,5). Intricate architecture enables hnRNP K to facilitate mRNA biosynthesis (6), transcriptional regulation (7) and signal transduction. Cytoplasmic hnRNP K expression is increased in oral squamous cell carcinoma and pancreatic cancer and may be a potential prognostic factor (8,9). hnRNP K coordinates with p53 to regulate its target gene transcription in response to DNA damage. Proteasome degradation of hnRNP K is mediated by E3 ligase MDM2 (10). The interaction between hnRNP K and c-Src leads to hnRNP K phosphorylation, which allows for hnRNP K activation of silenced mRNA translation (11). |
| 存放说明 | -20C |
| 计算分子量 | 58-62 |
Western blot analysis of extracts from HeLa and Hep G2 cells using hnRNP K (A222) Antibody. 使用hnRNP K (A222) Antibody，免疫印迹（Western Blotting）分析HeLa和HepG2细胞系提取物。 |
