| 货号 | 4275S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/E-P |
| 目标/特异性 | Granyzme B Antibody detects endogenous levels of total Granzyme B protein. |
| 使用方法 | WB(1:1000) E-P (1:100) |
| 供应商 | CST |
| 背景 | Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3). |
| 存放说明 | -20C |
| 计算分子量 | 30-37 |
Western blot analysis of recombinant mouse and human Granzyme B (5 ng) and extracts from the natural killer cell line NK-92, using Granyzme B Antibody. Western blot 分析重组小鼠和人Granzyme B (5 ng) 及自然杀伤细胞系 NK-92 的提取物，使用抗体为 Granzyme B Antibody。 | |
ELISA analysis of recombinant human Granzyme B, using Granzyme B Antibody. ELISA 分析重组人Granzyme B，使用抗体为 Granzyme B Antibody。 |
