Filamin B Antibody
货号：
8949S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8949S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Filamin B Antibody recognizes endogenous levels of total filamin B protein. This antibody detects a 100 kDa background band of unknown origin. Based on the amino acid sequence, this antibody is not expected to cross-react with filamin A or filamin C. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Filamins are a family of dimeric actin binding proteins that function as structural components of cell adhesion sites. They also serve as a scaffold for subcellular targeting of signaling molecules (1). The actin binding domain (alpha-actinin domain) located at the amino terminus is followed by as many as 24 tandem repeats of about 96 residues and the dimerization domain is located at the carboxy terminus. In addition to actin filaments, filamins associate with other structural and signaling molecules such as beta integrins, Rho/Rac/Cdc42, PKC, and the insulin receptor, primarily through the carboxy-terminal dimerization domain (1-3). Filamin A, the most abundant, and filamin B are widely expressed isoforms, while filamin C is predominantly expressed in muscle (1). Filamin A is phosphorylated by PAK1 at Ser2152, which is required for PAK1-mediated actin cytoskeleton reorganization (4). |
| 存放说明 | -20C |
| 计算分子量 | 280 |
参考图片Western blot analysis of extracts from various cell lines using Filamin B Antibody.使用Filamin B抗体对多种细胞提取物进行western blot分析。 |
