CLIP1/CLIP170 Antibody
货号：
8977S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 8977S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CLIP1/CLIP170 Antibody recognizes endogenous levels of total CLIP1/CLIP170 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Microtubules (MTs) are polarized filaments composed of α/β tubulin heterodimers. The slower growing (minus) ends of MTs are located at centrosomes, and the faster growing (plus) ends extend into the cell periphery. Regulation of MT dynamics is important for multiple cellular functions, including cell division, migration, adhesion, membrane trafficking, and polarity (reviewed in 1).
Cytoplasmic linker protein 1/170 (CLIP1/CLIP170) localizes to the plus ends of MTs (2), and binds to the Rac1/cdc42 effector protein IQGAP1. This complex is involved in establishing cell polarity (3).
CLIP1/CLIP170 also facilitates MT-dependent organelle transport (4), and phosphorylation of CLIP1/CLIP170 by PLK1 and CK2 is required for efficient microtubule–kinetochore attachments in mitosis (5). |
| 存放说明 | -20C |
| 计算分子量 | 170 |
参考图片Western blot analysis of extracts from various cell lines using CLIP1/CLIP170 Antibody.使用CLIP1/CLIP170抗体对多种细胞提取物进行western blot分析。 |
