CHD8 Antibody
货号：
7656S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 7656S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CHD8 Antibody recognizes endogenous levels of total CHD8 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | CHD8 belongs to the chromodomain helicase DNA-binding (CHD) family of ATP-dependent chromatin remodeling proteins (1). The CHD family of proteins has been shown to play an important role in regulating gene expression by utilizing the energy derived from ATP hydrolysis to alter chromatin architecture (1,2). The nine CHD family members are characterized by the presence of two tandem chromodomains in the N-terminal region and an SNF2-like ATPase domain near the central region of the protein (2-4). In addition, CHD8 contains three CR (conserved region) domains, a SANT (switching-defective protein 3, adaptor 2, nuclear receptor co-repressor, transcription factor IIB)-like domain, two BRK (brahma and kismet) domains and a DNA-binding domain (2). The chromatin remodeling activity of CHD8 has been shown to be important for the regulation of a wide variety of genes, such as the HOX genes (5) and genes that are driven by β-catenin (6), p53 (7), estrogen receptor (8), or androgen receptor (9). CHD8 can also interact with the insulator binding protein CTCF and is required for CTCF insulator activity at multiple gene loci (10). |
| 存放说明 | -20C |
| 计算分子量 | 290 |
参考图片Western blot analysis of extracts from SH-SY5Y and HeLa cells using CHD8 Antibody. 使用CHD8 Antibody，免疫印迹(Western blot)分析SH-SY5Y和HeLa细胞中CHD8蛋白水平。 |
