ARK5 Antibody
货号：
4458S 基本售价：
3360.0 元 规格：
-
产品信息
概述| 货号 | 4458S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ARK5 Antibody detects endogenous levels of total ARK5 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | AMP-activated protein kinases (AMPKs) constitute a serine/threonine protein kinase family, which is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis (1). AMPKα1, AMPKα2, MELK and SNARK are the catalytic subunits in the family (2). Recently, AMPK-related protein kinase ARK5 was identified, which shares 84% similarity with the sequence of the catalytic domain of SNARK (2). In vitro, Akt phosphorylates ARK5 at Ser600. This phosphorylation activates ARK5, which in turn results in the increased phosphorylation of the SAMS peptide, an AMPK consensus substrate (2). In vivo experiments showed that Akt-activated ARK5 is critical for the survival of cells under glucose starvation (2). Furthermore, studies also linked ARK5 to tumor invasion (3, 4). Overexpressed ARK5 leads to higher tumor growth rate (3). For example, the overexpression of ARK5 in pancreatic tumor cell line PANC-1 significantly elevates its metastasis in the liver (4). |
| 存放说明 | -20C |
| 计算分子量 | 78 |
参考图片Western blot analysis of extracts from L929 and C33A cells, using ARK5 Antibody. Wetern blot检测L929和C33A 提取物，所用抗体为ARK5 Antibody |
