| 货号 | 4832S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:50) |
| 供应商 | CST |
| 背景 | APS is an SH2 and PH domain-containing adaptor protein closely related to Lnk and SH2-B (1). APS was identified as a substrate for many receptor tyrosine kinases including TrkA, insulin receptor, c-Kit and PDGF receptor (2). Tyrosine phosphorylation of APS provides docking sites for downstrean signaling components, mediating diverse signaling pathways. APS plays quite different roles in RTK signaling. Overexpression of APS has been shown to inhibit PDGF-induced mitogenicity, which may result from APS/c-Cbl-mediated PDGF receptor degradation (3). However, APS promotes enhanced mitogenicity in response to insulin stimulation (4). The striking difference in APS-mediated signaling between the different RTKs could lie in the mode of interaction with the respective receptor. |
| 存放说明 | -20C |
| 计算分子量 | 90 to 95 |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using APS Antibody in the presence of control peptide (left) or antigen specific peptide (right).免疫组织化学方法检测石蜡包埋的人结肠癌组织，使用的抗体是APS Antibody。左侧使用的是对照肽段，右侧使用的是抗原特异性肽段。 | |
Western blot analysis of extracts from various cell lines, using APS Antibody.western blot方法检测细胞提取物：用c-Abl抗体处理各种细胞系，使用APS抗体。 | |
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, showing cytoplasmic localization using APS Antibody.免疫组织化学方法检测石蜡包埋的人前列腺癌组织，使用APS抗体显示胞质位置。 | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using APS Antibody.免疫组织化学方法检测石蜡包埋的人肺癌组织，使用APS抗体。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using APS Antibody.免疫组织化学方法检测石蜡包埋的人乳腺癌组织，使用APS抗体。 | |
Immunohistochemical analysis of paraffin-embedded human non-Hodgkins lymphoma, using APS Antibody.免疫组织化学方法检测石蜡包埋的人非霍奇金淋巴瘤组织，使用APS抗体。 |
