| 货号 | 3437S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | AMPA Receptor (GluR 3) Antibody detects endogenous levels of total GluR 3 protein. The antibody is not predicted to detect other AMPA receptors subunits (e.g. GluR 1, GluR 2 or GluR 4) based on sequence homology of the antigen. |
| 使用方法 | WB(1:1000) IP (1:50) |
| 供应商 | CST |
| 背景 | AMPA- (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs (1). GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission (2). Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Retts syndrome, amyotrophic lateral sclerosis and Alzheimer disease (3). |
| 存放说明 | -20C |
| 计算分子量 | 100 |
Western blot analysis of extracts from rat brain and human cerebellum using AMPA Receptor (GluR 3) Antibody. Western blot分析大鼠大脑和人小脑提取物，使用的抗体是AMPA Receptor (GluR 3) Antibody 兔多抗。 |
