| 货号 | 81557S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W IP |
| 目标/特异性 | CUTL1 Antibody recognizes endogenous levels of total CUTL1 protein. It recognizes the p200 isoform (the full-length) and is not expected to recognize the p110 and p75 isoforms. |
| 使用方法 | WB(1:1000) IP (1:200) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | CUTL1 (Cut-like 1), also known as CUX1 (Cut homeobox 1) (CUX1), is a transcription factor that has been implicated in many cellular processes in different tissues, such as cell migration, neuronal differentiation, and DNA repair (1-5). CUTL1 expression and activities are altered in cancer. Research studies have shown the CUTL1 gene to be a frequent target of loss-of-heterozygocity in various cancers (6,7). On the other hand, CUTL1 expression is elevated in many cancers and is associated with shorter disease-free survival (8). These accumulating evidence suggest that decreased CUTL1 expression promote tumor initiation and increased CUTL1 expression facilitates tumor progression (9). While full-length CUTL1 is about 200 kDa (p200), short forms p110 and p75 can also be generated by proteolytic processing and alternative transcription initiation site, respectively (10, 11). |
| 存放说明 | -20C |
| 计算分子量 | 200 |
| 参考文献 | 1 . Rodríguez-Tornos, F.M. et al. (2016) Neuron 89, 494-506. 2 . Ramdzan, Z.M. et al. (2015) Oncotarget 6, 3613-26. 3 . Ramdzan, Z.M. et al. (2014) PLoS Biol 12, e1001807. 4 . Kedinger, V. et al. (2009) J Biol Chem 284, 27701-11. 5 . Vadnais, C. et al. (2012) Nucleic Acids Res 40, 4483-95. 6 . McNerney, M.E. et al. (2013) Blood 121, 975-83. 7 . Ramdzan, Z.M. and Nepveu, A. (2014) Nat Rev Cancer 14, 673-82. 8 . Michl, P. et al. (2005) Cancer Cell 7, 521-32. 9 . Hulea, L. and Nepveu, A. (2012) Gene 497, 18-26. 10 . Moon, N.S. et al. (2001) Mol Cell Biol 21, 6332-45. 11 . Goulet, B. et al. (2002) Cancer Res 62, 6625-33. |
Western blot analysis of extracts from HeLa, HCT-15, and K-562 cells using CUTL1 Antibody. |
